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our Focus

The primary focus of Sharon Lee Family Health Care at the Doc Shop (5407 Johnson Drive in Mission, KS) is the prevention and treatment of sexually transmitted diseases and particularly to help people with HIV and other chronic viral illnesses optimize their health to live full lives. Call 913-362-0220
HIV Treatment Information- Shots in place of pills
You may have an interest in the shot to treat HIV. It is good in that you do not have to take pills every day. Here are more details on dosing:
The monthly injectable medication – Cabenueva, is offered at the Doc Shop. We know that every two months would be easier than coming into the office once monthly. But, we do not currently recommend it for every two months. Studies showed that the medicine dosed every 8 weeks failed three times more often than every 4 weeks.
DETAILS- Here are the data from a 3b study by the Pharmaceutical Company- ViiV, known as ATLAS 2-M:
A total of 1045 people with HIV were treated for 152 weeks with either: A) Cabotegravir (CAB) + rilpivirine (RPV) dosed intramuscularly (400/600 mg) as 2- 2cc shots monthly orB) Cabotegravir (CAB) + rilpivirine (RPV) dosed intramuscularly (600/900 mg) as 2- 3cc shots every 2 months
The hope was these two dosing regimens would be the same. The study used a calculation to determine, not that the study protocols were the same or equivalent; but that every 2 month dosing (B) is statistically non-inferior (not worse than) the monthly dosing (A). This type of trial has potential flaws, most importantly how the non-inferiority number is chosen. In this case it was set at 4%. That means one arm of the trial is considered “non-inferior” to the other if the difference between the outcomes is less than 4% (4 in each 100).
Results: Group A (every 4 wks) Group B (every 8 wks)Number of people 523 522Failures (HIV broke through) 5 14
The study was reported out as meeting the 4% noninferiority threshold because statistically the 2.7% (Group B- 14 people of 522) failure rate is not inferior (less than 4%) of the 1% (Group A- 5 people of 523) failure rate.
Of the two arms of the trial which would you rather be in? Note that more than twice the number of people failed treatment during the 152 weeks of the trial if they were dosed every 8 rather than every 4 weeks. Most who experienced treatment failure developed evidence of resistance to Rilpivirine.
Also:The medicine disappears from the blood at a mean concentration to ½ dose at 5.6-11.5 weeks for the CAB and 13-28 weeks for the RPV.
Mean concentrations of the RPV show it stays in the body longer than the CAB. That means RPV may be the only drug in the system if someone either doesn’t come in time for their dose or if someone metabolizes the medication quickly. During the decades we have studied HIV, we learned that one medicine is not enough to control HIV. If the RPV stands alone, it likely will not control the virus. RPV resistance will be more likely to develop (which can mean the entire class of integrase inhibitor medicines is useless).
*Doc Lee's Opinion Injectable dosing of Cabenueva/Rilpivirine is a work in progress. Once every 4 weeks is safer for most patients than once every 8 weeks .
SLee MD
Click here for More Cabenuva Information 
Diagnosis, Treatment & Prevention of HIV
Oops! If you believe you may have been exposed to HIV, or other infections, please call right away. The Doc Shop (913-362-0220) offers same-day or next-day treatment.
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More Effective than Chill Pills...to prevent HIV- If you are worried you may have been exposed to HIV- Call to see if an after-exposure (Post-Exposure-Prophylaxis) treatment is right for you. *Doc Lee's Opinion The studies on post-exposure prophylaxis preventive treatment have shown a reduction in transmission of about 80%. But, the medicine must be started as soon as possible after transmission - best within 24 hours.
Please call the Doc Shop right away if you believe you have been exposed to any sexually transmitted disease. We will help you sort your risks and determine the best options for prevention or treatment. Call 913-362-0220.
THE DOC ON HIV
THE DOC ON HEPATITIS (B, C)
THE DOC ON MONKEYPOX
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CONTACT INFO for Dr. sharon lee at the Doc shop
913-362-0220
www.DOCShop.Biz
ADDRESS
5407 Johnson Drive
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